Summary - NDMA

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Nitrosodimethylamine (NDMA) (CAS 62-75-9)

Other names for Nitrosodimethylamine are Methanamine, N-methyl-N-nitroso-; Dimethylamine, N-nitroso-; Dimethylnitrosamine; DMN; DMNA; N-Nitroso-N,N-Dimethylamine; (CH3)2NNO; Dimethylnitrosamin; Dimethylnitrosoamine; N-Methyl-N-nitrosomethanamine; N,N-Dimethylnitrosamine; NDMA; Nitrosodimethylamine; Rcra waste number P082; NSC 23226

 

NDMA is a part of a group of substances, nitrosamines. NDMA has been classified as probable carcinogen in humans by International Agency for Research on Cancer (IARC), as Group 2A (1) and by the US Environmental Protection Agency (EPA). (2)

NDMA was formerly used in production of rocket fuel, it could also be found as a by-product from tanneries, pesticides and rubber factories.(3) NDMA can also be formed as a by-product during disinfection process (N-DBPs) in drinking water after cleaning using chlorine and chlorinated substances (4, 5) by oxidation from unsymmetrical dimehtylhydrazine (UDMH) (6) or chlorinated unsymmetrical dialkylhydrazine intermetidate (CI-UDMH). (7)

NDMA has been found in soil, waste and drinking water as well as in some food products that contains nitrite mostly smoked or dried fish and meet. (3)

Major source of human exposure to NDMA is tobacco smoke or chewing tobacco. Dietary intake of NDMA is trough drinking water but also from food like meet, mostly smoked, alcoholic beverages such as beer, fish and cheese. (3)